LB-01, Lento Bio’s lead asset, is a small molecule capable of significantly reducing lens stiffness. Natural protective thiols such as glutathione must be imported into our lenses to maintain quality control of long-lived crystallin proteins. With age, levels of these compounds in the lens is reduced, leading to lens stiffening and presbyopia. LB-01 is designed to optimally penetrate the difficult barriers of the cornea and lens, enabling it to take over lost quality control functions. In 8-month old mice, 1-month long eyedrop treatment resulted in 68% restoration of lens stiffness* lost to aging (from that of a 2-month old mouse).